CVE-2021-25252 Denial of service in Trend Micro Virus Scan API (VSAPI) Engine

What is CVE-2021-25252?

CVE-2021-25252 is a medium-severity denial of service vulnerability in Trendmicro Apex One, published on 3 Mar 2021. It can only be exploited from the same machine or local network, with no action from the victim.

Official description

Trend Micro's Virus Scan API (VSAPI) and Advanced Threat Scan Engine (ATSE) - are vulnerable to a memory exhaustion vulnerability that may lead to denial-of-service or system freeze if exploited by an attacker using a specially crafted file.

Weakness: CWE-400

Which versions are affected by CVE-2021-25252?

It affects 19 products.

Products include Trendmicro Apex Central, Trendmicro Apex One, Trendmicro Cloud Edge, Trendmicro Control Manager, Trendmicro Deep Discovery Analyzer, Trendmicro Deep Discovery Email Inspector and 13 more.

How do I fix CVE-2021-25252?

No fix has been published for CVE-2021-25252 yet. Limit exposure of the affected software until one is available.

Upgrade, then put limits on request size, rate and nesting depth so one client cannot exhaust the service. More about Denial of service.

Is CVE-2021-25252 being exploited?

There is no known exploitation of CVE-2021-25252 in the wild and no public exploit code.

Other vulnerabilities in Trendmicro Apex One

• CVE-2022-26871 Trend Micro Apex Central Arbitrary File Upload Exploited Critical 9.8
• CVE-2025-69258 Code injection in Trend Micro Apex Central Critical 9.8
• CVE-2025-49219 Deserialization in Trend Micro Apex Central Critical 9.8
• CVE-2025-49220 Deserialization in Trend Micro Apex Central Critical 9.8
• CVE-2023-52324 File upload in Trend Micro Apex Central High 8.8

All Trendmicro Apex One vulnerabilities

Sources

• CVE record
• NVD
• OSV
• GitHub advisory
• How this page is made

Also known as GHSA-f392-jc49-593j.