# CVE-2025-12921: OpenClinica Community Edition CRF Data Import ImportCRFData xml injection

> Remote attackers can exploit XML injection in the CRF Data Import feature to execute code or read data, requiring immediate mitigation as no vendor fix is available.

- **Severity:** Medium 5.3 (`CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N/E:P`)
- **Exploited in the wild:** Not known
- **Login needed:** Any signed-in user
- **Attackable:** Over the internet
- **Victim action needed:** Not needed
- **Fix available:** No
- **Published:** 9 Nov 2025
- **Updated:** 14 Nov 2025
- **Also known as:** GHSA-jxxq-v434-pmg5

## What is CVE-2025-12921?

CVE-2025-12921 is a medium-severity vulnerability in OpenClinica Community Edition, published on 9 Nov 2025. Any signed-in user can exploit it over the network, with no action from the victim.

### Official description

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

Weakness: CWE-91 (XML Injection), CWE-74 (Improper Neutralization of Special Elements in Output Used by a Downstream Component)

## Which versions are affected by CVE-2025-12921?

It affects 1 product.


Products: Openclinica Openclinica.

## How do I fix CVE-2025-12921?

No fix has been published for CVE-2025-12921 yet. Limit exposure of the affected software until one is available.

## Is CVE-2025-12921 being exploited?

It is not confirmed as exploited in the wild, but public exploit code for CVE-2025-12921 exists.

## Other vulnerabilities in OpenClinica Community Edition

- [CVE-2022-24831](https://insights.sbomify.com/CVE-2022-24831/): Improper Neutralization of Special Elements used in an SQL Command ('SQL Injection') in OpenClinica (high 8.3)
- [CVE-2022-24830](https://insights.sbomify.com/CVE-2022-24830/): Path Traversal in OpenClinica (medium 6.5)
- [CVE-2025-12922](https://insights.sbomify.com/CVE-2025-12922/): OpenClinica Community Edition CRF Data Import ImportCRFData path traversal (medium 5.3)

## Fix prompt for AI coding agents

```text
Check this codebase for CVE-2025-12921 and fix it if it is affected.

What it is: CVE-2025-12921 is a medium-severity vulnerability in OpenClinica Community Edition, published on 9 Nov 2025. Any signed-in user can exploit it over the network, with no action from the victim.
Exploitation: It is not confirmed as exploited in the wild, but public exploit code for CVE-2025-12921 exists.

Affected product: OpenClinica Community Edition. No package-level version data is available, so check the vendor advisory linked from the reference page.

Task:
1. Search the dependency manifests and lockfiles (for example package.json, package-lock.json, requirements.txt, poetry.lock, uv.lock, pom.xml, build.gradle, go.mod, Cargo.lock, Gemfile.lock) and any Dockerfiles for the affected packages, including transitive dependencies.
2. If an affected version is in use, upgrade it to the fixed version for its release line with the project's package manager, so the lockfile is regenerated. Prefer the smallest upgrade that fixes it.
3. If there is no fix, or the upgrade would break the build, do not guess: explain the risk and the safest workaround instead.
4. Run the tests and summarise what changed and why.
5. If nothing in the project is affected, say so and change nothing.

Reference: https://insights.sbomify.com/CVE-2025-12921/ (Markdown: https://insights.sbomify.com/CVE-2025-12921/index.md)
```

## Sources

- CVE record: https://www.cve.org/CVERecord?id=CVE-2025-12921
- NVD: https://nvd.nist.gov/vuln/detail/CVE-2025-12921
- OSV: https://osv.dev/vulnerability/CVE-2025-12921

---
From sbomify Insights: https://insights.sbomify.com/CVE-2025-12921/
Summaries are generated and may contain mistakes; the official description above is the record.