CVE-2025-58757 MONAI's unsafe use of Pickle deserialization may lead to RCE

High 8.8 Published Updated

MONAI library allows remote code execution via unsafe pickle deserialization in data utilities, affecting healthcare AI applications.

Exploited in the wild
Not known
Login needed
Not needed
Attackable
Over the internet
Victim action needed
A user has to click or open something
Fix
Available

What is CVE-2025-58757?

CVE-2025-58757 is a high-severity unsafe deserialization vulnerability in Project-MONAI MONAI, published on 8 Sep 2025. An attacker can exploit it over the internet without logging in, and only if a user opens a file or follows a link.

Official description

MONAI (Medical Open Network for AI) is an AI toolkit for health care imaging. In versions up to and including 1.5.0, the `pickle_operations` function in `monai/data/utils.py` automatically handles dictionary key-value pairs ending with a specific suffix and deserializes them using `pickle.loads()` . This function also lacks any security measures. The deserialization may lead to code execution. As of time of publication, no known fixed versions are available.

Weakness: CWE-502

Which versions are affected by CVE-2025-58757?

3 open source packages ship an affected version, including monai. It affects 1 product.

PackageAffectedFixed in
monai PyPIAll versions1.5.1
monai PyPIAll versions1.5.1
monai PyPIAll versions1.5.1rc1

Products include Monai Medical Open Network for Ai.

How do I fix CVE-2025-58757?

Upgrade monai to a fixed version for your release line: 1.5.1 or 1.5.1rc1.

Upgrade, and only deserialise data from trusted sources or with an allow-list of types. More about Unsafe deserialization.

Is CVE-2025-58757 being exploited?

It is not confirmed as exploited in the wild, but public exploit code for CVE-2025-58757 exists.

Sources

Also known as GHSA-p8cm-mm2v-gwjm, PYSEC-2025-142.

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