# CVE-2026-100845: MONAI before 1.6.0 Remote Code Execution via NumpyReader

> Attackers can execute arbitrary code by crafting malicious .npy files loaded via MONAI's NumpyReader due to unsafe pickle deserialization.

- **Severity:** High 8.5 (`CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:P/VC:H/VI:H/VA:H/SC:N/SI:N/SA:N`)
- **Exploited in the wild:** Not known
- **Login needed:** Not needed
- **Attackable:** Local or same network only
- **Victim action needed:** A user has to click or open something
- **Fix available:** Yes
- **Published:** 27 Sep 2026
- **Updated:** 28 Sep 2026
- **Also known as:** GHSA-4jj3-3266-2688, GHSA-wg9g-w2j2-8pgr, PYSEC-2026-4020

## What is CVE-2026-100845?

CVE-2026-100845 is a high-severity unsafe deserialization vulnerability in Project-MONAI MONAI, published on 27 Sep 2026. It can only be exploited from the same machine or local network, and only if a user opens a file or follows a link.

### Official description

MONAI before 1.6.0 contains an unsafe deserialization vulnerability in the NumpyReader class that unconditionally uses numpy.load with allow_pickle=True when loading .npy and .npz files. Attackers can craft malicious .npy files with pickle payloads that execute arbitrary code when loaded through MONAI's standard data pipeline.

Weakness: CWE-502 (Deserialization of Untrusted Data)

## Which versions are affected by CVE-2026-100845?

3 open source packages ship an affected version, including monai. It affects 1 product.


| Package | Ecosystem | Affected | Fixed in |
| --- | --- | --- | --- |
| `monai` | PyPI | All versions | 1.6.0 |
| `monai` | PyPI | All versions | 1.6.0 |
| `monai` | PyPI | All versions | 1.6.0 |

Products: Project-Monai Monai.

## How do I fix CVE-2026-100845?

Upgrade monai to 1.6.0 or later.

## Is CVE-2026-100845 being exploited?

It is not confirmed as exploited in the wild, but public exploit code for CVE-2026-100845 exists.

## Other vulnerabilities in Project-MONAI MONAI

- [CVE-2026-100846](https://insights.sbomify.com/CVE-2026-100846/): MONAI before 1.5.2 Remote Code Execution via Pickle Deserialization (high 8.8)
- [CVE-2026-100844](https://insights.sbomify.com/CVE-2026-100844/): MONAI before 1.6.0 OS Command Injection via dataset_name_or_id (high 8.6)
- [CVE-2026-100840](https://insights.sbomify.com/CVE-2026-100840/): MONAI through 1.6.0 Remote Code Execution via bundle configuration (high 8.5)
- [CVE-2026-100841](https://insights.sbomify.com/CVE-2026-100841/): MONAI through 1.6.0 PersistentDataset Remote Code Execution via Pickle Cache (high 8.5)
- [CVE-2026-100843](https://insights.sbomify.com/CVE-2026-100843/): MONAI before 1.6.0 Remote Code Execution via algo_from_pickle (high 8.5)

## Fix prompt for AI coding agents

```text
Check this codebase for CVE-2026-100845 and fix it if it is affected.

What it is: CVE-2026-100845 is a high-severity unsafe deserialization vulnerability in Project-MONAI MONAI, published on 27 Sep 2026. It can only be exploited from the same machine or local network, and only if a user opens a file or follows a link.
Exploitation: It is not confirmed as exploited in the wild, but public exploit code for CVE-2026-100845 exists.

Affected packages and fixed versions:
- monai (PyPI): affected all versions; fixed in 1.6.0
- monai (PyPI): affected all versions; fixed in 1.6.0
- monai (PyPI): affected all versions; fixed in 1.6.0

Task:
1. Search the dependency manifests and lockfiles (for example package.json, package-lock.json, requirements.txt, poetry.lock, uv.lock, pom.xml, build.gradle, go.mod, Cargo.lock, Gemfile.lock) and any Dockerfiles for the affected packages, including transitive dependencies.
2. If an affected version is in use, upgrade it to the fixed version for its release line with the project's package manager, so the lockfile is regenerated. Prefer the smallest upgrade that fixes it.
3. If there is no fix, or the upgrade would break the build, do not guess: explain the risk and the safest workaround instead.
4. Run the tests and summarise what changed and why.
5. If nothing in the project is affected, say so and change nothing.

Reference: https://insights.sbomify.com/CVE-2026-100845/ (Markdown: https://insights.sbomify.com/CVE-2026-100845/index.md)
```

## Sources

- CVE record: https://www.cve.org/CVERecord?id=CVE-2026-100845
- NVD: https://nvd.nist.gov/vuln/detail/CVE-2026-100845
- OSV: https://osv.dev/vulnerability/CVE-2026-100845

---
From sbomify Insights: https://insights.sbomify.com/CVE-2026-100845/
Summaries are generated and may contain mistakes; the official description above is the record.